engleski

POSITIVE EFFECT OF n-3 PUFA ON THE LEVEL OF OXIDATIVE STRESS AND INFLAMMATORY RESPONSE

Inflammation and oxidative stress are now recognized as major factors involved in the pathogenesis of different diseases, like cardiovascular diseases or overweight/obesity. Increased consumption of omega-3 polyunsaturated fatty acids (n-3 PUFAs) is associated with decreased level of oxidative stress and anti- inflammatory effects possibly due to reduced arachidonic acid (AA)-derived eicosanoids reduced triglyceride levels, and inhibition of platelet aggregation. Most studies on the effect of n-3 PUFAs were performed on chronic patients and with the use of n-3 PUFAs in the form of supplements (capsules). The relationship between human health and food and the way in which food can affect the maintenance and improvement of human health is increasingly in the focus of the researchers. Currently, Scientific Center of Excellence for Personalized Health Care Osijek investigates the influence of n-3 PUFA enriched eggs on the endothelial function of the blood vessels and the change of the level of oxidative stress in cardiovascular patients and in healthy, young people and athletes. These studies have so far shown that n-3 PUFAs lowers the level of oxidative stress in healthy young people and have a positive effect on the microcirculation even in people with normal endothelial function, suggesting their protective effects in cardiovascular diseases.

endothelial function ; functional foods ; inflammation ; n-3 PUFA ; oxidative stress

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