Immunoregulatory properties of deciduas macrophages (CROSBI ID 488425)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Sedlmayr, Peter ; Ćupurdija, Kristijan ; Azzola, Dagmar ; Dohr, Gottfried ; Wintersteiger, Reinhold ; Morales, Pedro ; Petrof, Margaret G. ; Hunt, Joan S. ; Gratchev, Alexei ; Goerdt, Sergij
engleski
Immunoregulatory properties of deciduas macrophages
About 15-20 % of bone marrow derived cells in the endometrium and the decidua are CD14-positive macrophages coexpressing the scavenger receptor CD163. The costimulatory molecule CD86 (B7-2) but not CD80 (B7-1) is found expressed on first trimester and term decidua macrophages (D-Mph). The number of D-Mph increases at the implantation site in the basal decidua, where they are in contact with the HLA-Gpositive invading extravillous cytotrophoblast. As DMph express the inhibitory receptors CD85d (ILT4, LIR-2) and CD85e (ILT2, LIR-1), they are potentially susceptible to inhibition by class Ia and class Ib molecules. D-Mph may have specific functions relating to successful pregnancy, and phenotypic and functional properties may differ between early and term pregnancy. A number of data make their molecular repertoire comparable to those of alternatively activated macrophages which are immunosuppressive. For instance, first trimester decidua macrophages express IL-10 and the MS-1 high molecular weight antigen on the cell surface fibronectin and F XIIIa are detectable. Functional data are required to complement these studies.
immunoregulatory properties ; decidua macrophages
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Podaci o prilogu
142-142.
2002.
nije evidentirano
objavljeno
10.1034/j.1600-0897.2002.00024.x
Podaci o matičnoj publikaciji
American journal of reproductive immunology
Rukavina, Daniel ; Gill, Thomas J. ; Clark, David A.
John Wiley & Sons
1046-7408
Podaci o skupu
8th Congress of the Alps Adria Society for Immunology of Reproduction
pozvano predavanje
07.09.2002-10.09.2002
Weimar, Njemačka
Povezanost rada
Temeljne medicinske znanosti