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Immunoregulatory properties of deciduas macrophages (CROSBI ID 488425)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija

Sedlmayr, Peter ; Ćupurdija, Kristijan ; Azzola, Dagmar ; Dohr, Gottfried ; Wintersteiger, Reinhold ; Morales, Pedro ; Petrof, Margaret G. ; Hunt, Joan S. ; Gratchev, Alexei ; Goerdt, Sergij Immunoregulatory properties of deciduas macrophages // American journal of reproductive immunology / Rukavina, Daniel ; Gill, Thomas J. ; Clark, David A. (ur.). 2002. str. 142-142 doi: 10.1034/j.1600-0897.2002.00024.x

Podaci o odgovornosti

Sedlmayr, Peter ; Ćupurdija, Kristijan ; Azzola, Dagmar ; Dohr, Gottfried ; Wintersteiger, Reinhold ; Morales, Pedro ; Petrof, Margaret G. ; Hunt, Joan S. ; Gratchev, Alexei ; Goerdt, Sergij

engleski

Immunoregulatory properties of deciduas macrophages

About 15-20 % of bone marrow derived cells in the endometrium and the decidua are CD14-positive macrophages coexpressing the scavenger receptor CD163. The costimulatory molecule CD86 (B7-2) but not CD80 (B7-1) is found expressed on first trimester and term decidua macrophages (D-Mph). The number of D-Mph increases at the implantation site in the basal decidua, where they are in contact with the HLA-Gpositive invading extravillous cytotrophoblast. As DMph express the inhibitory receptors CD85d (ILT4, LIR-2) and CD85e (ILT2, LIR-1), they are potentially susceptible to inhibition by class Ia and class Ib molecules. D-Mph may have specific functions relating to successful pregnancy, and phenotypic and functional properties may differ between early and term pregnancy. A number of data make their molecular repertoire comparable to those of alternatively activated macrophages which are immunosuppressive. For instance, first trimester decidua macrophages express IL-10 and the MS-1 high molecular weight antigen on the cell surface fibronectin and F XIIIa are detectable. Functional data are required to complement these studies.

immunoregulatory properties ; decidua macrophages

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Podaci o prilogu

142-142.

2002.

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objavljeno

10.1034/j.1600-0897.2002.00024.x

Podaci o matičnoj publikaciji

American journal of reproductive immunology

Rukavina, Daniel ; Gill, Thomas J. ; Clark, David A.

John Wiley & Sons

1046-7408

Podaci o skupu

8th Congress of the Alps Adria Society for Immunology of Reproduction

pozvano predavanje

07.09.2002-10.09.2002

Weimar, Njemačka

Povezanost rada

Temeljne medicinske znanosti

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