Synthesis and binding or permethylated diamondoid ammonium salts (CROSBI ID 694173)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa
Podaci o odgovornosti
Alešković, Marija ; Jozepović, Ruža ; Roca, Sunčica ; Bregović, Nikola ; Šekutor, Marina
engleski
Synthesis and binding or permethylated diamondoid ammonium salts
Supramolecular complexes are stabilized by non-covalent interactions between the host and the guest molecule. Molecular recognition studies can give insight into many processes occurring in nature and prove useful for technological applications. It was recently demonstrated that functionalized adamantane and diamantane ammonium salts are suitable guests for cucurbituril hosts. Moreover, some diamantane derivatives are capable of extremely tight binding with cucurbiturils in water, forming complexes with attomolar dissociation constants. Such ultrastable complexes rival the strength of binding processes acting in biomolecular receptors (e.g., avidin-biotin). As a continuation of our research, we explored complexation of selected adamantane and diamantane ammonium salts with cyclodextrin host molecules. The binding strength was assessed as a function of diamondoid salt size, functional group position and cyclodextrin cavity size. By changing these parameters, a structure-selectivity relationship can be determined and next generation of guests proposed. Various NMR spectroscopic techniques and ITC measurements were employed to determine the stability constants and explore host-guest interactions. Computation methods were used to gain further insight into structural features of formed complexes and to better understand the factors governing their stabilities.
permethylated diamondoid salts ; synthesis ; inclusion complex ; thermodynamics
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Podaci o prilogu
37-37.
2020.
objavljeno
Podaci o matičnoj publikaciji
Adriatic NMR Conference : Book of Abstracts
Bregović, Nikola ; Namjesnik, Danijel ; Novak, Predrag ; Parlov Vuković, Jelena
Zagreb: Kemijski odsjek Prirodoslovno-matematičkog fakulteta Sveučilišta u Zagrebu ; Geološki odsjek Prirodoslovno-matematičkog fakulteta Sveučilišta u Zagrebu
978-953-6076-58-1
Podaci o skupu
4th Adriatic NMR conference 2020
poster
22.09.2020-24.09.2020
Peroj, Hrvatska; Vodnjan, Hrvatska