engleski

Elevated Serum Lipids in Veterans with Combat-related Chronic Posttraumatic Stress Disorder

To assess possible differences in serum cholesterol, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglycerides, arteriosclerosis index, established risk factor (ERF) of arteriosclerosis, and 10-year risk for coronary disease according to the Adult Treatment Panel III (ATP-III) between veterans with combat-related posttraumatic stress disorder (PTSD) and a control group consisting of patients with major depressive disorder. We determined serum cholesterol, LDL-C, HDL-C, and triglycerides in the patients with PTSD (n = 103) and patients with major depressive disorder (n = 92), using the enzyme-assay method. Al, ERF, and ATP-III were calculated from cholesterol, LDL-C, and HDL-C levels. The groups were matched in age and body mass index (BMI). Patients with major depressive disorder were chosen as a control group because they do not have changes in serum lipids. Patients with combat-related PTSD had higher cholesterol (6.2 +/- 1.1 mmol/L vs 5.3 +/- 0.9 mmol/L ; p<0.001), LDL-C (3.9 +/- 0.7 mmol/L vs 3.5 +/- 1.0 mmol/L ; p=0.005), and triglycerides (2.9 +/- 2.3 mmol/L vs 1.5 +/- 0.5 mmol/L ; p<0.001), and lower HDL-C (1.0 +/- 0.3 mmol/L vs 1.3 +/- 0.2 mmol/L ; p<0.001) than the control group. Arteriosclerosis index (4.2 +/- 1.2 vs 3.7 +/- 1.7 ; p =0.050), ERF (6.4 +/- 1.9 vs 5.5 +/- 2.4 ; p=0.010), and ATP-III (12.1 +/- 3.3 vs 10.2 +/- 3.8 ; p<0.001) were higher in PTSD than in the control group. Elevated concentrations of serum lipids are associated with combat-related PTSD. This may imply that patients with combat-related PTSD are under a higher risk for arteriosclerosis.

arteriosclerosis; cholesterol; Croatia; lipoproteins; HDL cholesterol; lipoproteins; LDL cholesterol; stress disorders; post-traumatic; triglycerides; veterans

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