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Antibiotic-induced release of endotoxin : in-vitro comparison of meropenem and other antibiotics (CROSBI ID 80103)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Trautmann, Matthias ; Zick, Regine ; Rukavina, Tomislav ; Cross, Alan S. ; Marre, Reinhard Antibiotic-induced release of endotoxin : in-vitro comparison of meropenem and other antibiotics // Journal of antimicrobial chemotherapy, 41 (1998), 2; 163-169

Podaci o odgovornosti

Trautmann, Matthias ; Zick, Regine ; Rukavina, Tomislav ; Cross, Alan S. ; Marre, Reinhard

engleski

Antibiotic-induced release of endotoxin : in-vitro comparison of meropenem and other antibiotics

The influence of meropenem, a new carbapenem antibiotic, on cell morphology and in-vitro lipopolysaccharide (LPS) release from Escherichia coli was compared with that of imipenem, ceftazidime, tobramycin and ciprofloxacin. Free and cell-associated LPS was quantified by means of a capture ELISA method based on the recognition of E. coli LPS by monoclonal antibodies. Microscopically, meropenem was found to induce spheroplast formation similar to that seen with imipenem, while ceftazidime and ciprofloxacin induced filament formation. Free and cell-associated LPS levels were low in the presence of meropenem, imipenem, ciprofloxacin and tobramycin, but high in the presence of ceftazidime. Reduced endotoxin release appears to be a common property of carbapenem antibiotics. Morphological changes in bacteria in the presence of antibiotics do not predict their LPS-liberating effect since ciprofloxacin induced low levels of LPS despite cousing filament formation.

endotoxin; meropenem; antibiotic

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Podaci o izdanju

41 (2)

1998.

163-169

objavljeno

0305-7453

Povezanost rada

Kliničke medicinske znanosti

Indeksiranost