engleski

Experiments and theories of aging and longevity

Evolutionary theories of aging (programmed death of organisms due to limited number of somatic cell divisions, accumulated mutations, antagonistic pleiotropy, disposable soma theory), Michael Roses' fruit fly longevity experiment, critics of evolutionary theories of aging, theories of systemic aging, endocrine theories of aging, Baltimore longitudinal study of aging, progerias (Werner syndrome, Hutchinson-Guilford syndrome, Down syndrome, Cockayne syndrome, Ataxia teleangiectasia), caloric restriction, animal models of aging, Gompertz-Makeham curves, genetic instability and genetically programmed telomere shortening, oxidative damage due to reactive oxygen species, mitochondrial DNA mutations, histologic brain changes during normal aging, future prospects of aging research, including cloning.

aging; evolution; mutation; genetic instability; telomere shortening; oxidative damage; reactive oxygen species; mitochondrial DNA mutations; cloning

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