“One pot” pristup sintezi monodentatnih oksazolina s aromatskom jezgrom - asimetrična supstitucija prekursora u jednom koraku (CROSBI ID 703951)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa
Podaci o odgovornosti
Bakija, Marija ; Kirin, Srećko, I.
hrvatski
“One pot” pristup sintezi monodentatnih oksazolina s aromatskom jezgrom - asimetrična supstitucija prekursora u jednom koraku
The application of oxazoline ligands in asymmetric catalysis is successfully carried out in many important reactions with very high enantioselectivities [1]. However, the research accumulated so far has mainly been focused on utilizing bidentate bisoxazoline derivatives in catalysis, leaving the monodentate oxazoline ligands widely unexplored. Syntheses of more complex organic molecules often demand introduction of protection groups due to the large number of functional groups, which react in a non-selective fashion with various reagents. The introduction of protecting groups can be avoided by careful choice of the reagents and adjustment of reaction conditions. Following our work on metal-organic catalysts in which noncovalent interactions induce chirality [2, 3] we have synthesized monodentate oxazoline ligands for application in asymmetric catalysis. In this study we present a comparison of synthetic approaches via protecting groups and the “one pot” method for asymmetric substitution of benzene and naphthalene rings with oxazoline and peptide substituents with different substitution patterns. The prepared compounds are characterized using spectroscopic methods, namely 1H and 13C NMR, as well as mass spectrometry.
monodentatnih oksazolini ; kataliza
nije evidentirano
engleski
"One pot" approach to synthesizing monodentate oxazolines with an aromatic core – Asymmetric substitution of precursors in one step
The application of oxazoline ligands in asymmetric catalysis is successfully carried out in many important reactions with very high enantioselectivities [1]. However, the research accumulated so far has mainly been focused on utilizing bidentate bisoxazoline derivatives in catalysis, leaving the monodentate oxazoline ligands widely unexplored. Syntheses of more complex organic molecules often demand introduction of protection groups due to the large number of functional groups, which react in a non-selective fashion with various reagents. The introduction of protecting groups can be avoided by careful choice of the reagents and adjustment of reaction conditions. Following our work on metal-organic catalysts in which noncovalent interactions induce chirality [2, 3] we have synthesized monodentate oxazoline ligands for application in asymmetric catalysis. In this study we present a comparison of synthetic approaches via protecting groups and the “one pot” method for asymmetric substitution of benzene and naphthalene rings with oxazoline and peptide substituents with different substitution patterns. The prepared compounds are characterized using spectroscopic methods, namely 1H and 13C NMR, as well as mass spectrometry.
oxazoline ; catalysis ; monodentate
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
308-309.
2021.
objavljeno
Podaci o matičnoj publikaciji
Simpozij studenata doktorskih studija PMF-a : knjiga sažetaka = PhD Student Symposium 2021 : book of abstracts
Barišić, Dajana
Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu
978-953-6076-90-1
Podaci o skupu
5. Simpozij studenata doktorskih studija PMF-a = 5th Faculty of Science PhD Student Symposium
poster
24.04.2021-25.04.2021
Zagreb, Hrvatska