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Lower cortisol and higher ACTH levels in individuals with autism

Blood concentrations of pituitary hormones adrenocorticotropin (ACTH), prolactin, growth hormone, and adrenal hormone – cortisol were measured in 36 autistic and 27 control individuals. Individuals with autism had significantly lower serum concentrations of cortisol (p<10-6), and significantly higher concentrations of ACTH (p=0.002) than control age- and sex-mached subjects. Also, prolactin concentrations in autistic patients with epilepsy were significantly higher when compared with normal subjects. The observed hormonal changes indicate disfunctioning of the hypothalamo-pytuitary-adrenal axis in individuals with autism.

autism ; cortisol ; ACTH

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