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Effect of indomethacin on somatosensory evoked potentials after experimental spinal cord injury in rabbit (CROSBI ID 465856)

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Draganić, Pero ; Simonić, Ante Effect of indomethacin on somatosensory evoked potentials after experimental spinal cord injury in rabbit // Periodicum biologorum 99 (1997), suppl. 1 / Vitale, Branko (ur.). Zagreb: Hrvatsko prirodoslovno društvo, 1997. str. 37-37-x

Podaci o odgovornosti

Draganić, Pero ; Simonić, Ante

engleski

Effect of indomethacin on somatosensory evoked potentials after experimental spinal cord injury in rabbit

The effect of indomethacin on the recovery of somatosensory evoked potentials (SEPs) was evaluated in an experimental model of spinal cord impact injury in rabbits. Somatosensory evoked pontentials can provide a unique insight into the functioning of the nervous system since they result from the direct stimulation of sensory nerves. The spinal cord evoked potentials were recorded by using monopolar needle electrodes placed epidurally over the L1 and C7 segments after stimulation of the right peroneal nerve. Reference electrodes were placed in the corresponding paravertebral muscles and in a mid frontal area at Fz. The spinal cord impact injury (150 p cm) was performed under the pentob arbital anaesthesia (30 mg/kg iv.) SEPs were recorded just before the injury and eight days after the spinal cord injury. The spinal cord evoked potentials consisted of a small positive peak followed by a broad and high negative peak. Latencies of the maximal negativne peak were measured. Indomethacin, a potent inhibitor of endogenous prostaglandin synthesis was tested in the doses of 0.1; 0.3 and 1.0 mg/kg body weight (iv.). It was injected immediately after the injury and during the eight subsequent days. Spinal cord trauma provoked a latency increase of SEPs which indicate a problem in spinal conduction. Indomethacin attenuates alteration in SEPs, showing the significant effect in the dose ofd 1.0 mg/kg body weight.

idomethacin; somatosensory evoked potentials; spinal cord injury; rabbits

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Podaci o prilogu

37-37-x.

1997.

nije evidentirano

objavljeno

Podaci o matičnoj publikaciji

Periodicum biologorum 99 (1997), suppl. 1

Vitale, Branko

Zagreb: Hrvatsko prirodoslovno društvo

Podaci o skupu

Satellite Meeting Central Nervous System : Damage and Repair

poster

11.09.1997-13.09.1997

Malinska, Hrvatska

Povezanost rada

Kliničke medicinske znanosti