Nimodipine attenuates alteration in somatosensory evoked potentials after trauma to the spinal cord : an experimental study in rabbits (CROSBI ID 465857)
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Podaci o odgovornosti
Draganić, Pero ; Simonić, Ante
engleski
Nimodipine attenuates alteration in somatosensory evoked potentials after trauma to the spinal cord : an experimental study in rabbits
The recovery of somatosensory evoked potentials (SEPs) was examined in rabbits with spinal cord impact injury. Somatosensory evoked potnetials reflect the initial stages of the sensory information processing, so any dysfunction or damage of teh nerve cells leads to the abnormality in the wave form of the SEPs. The spinal cord evoked potentials were recorded by using epidural monopolar needle electrodes placed over the L1 and C7 segments after stimulation of the right peroneal nerve. Reference electrodes were placed in the corresponding paravertebral muscles and in a mid frontal area at Fz. The spinal cord impact injury (150 p cm) was performed under the pentobarbital anaesthesia (30 mg/kg iv). SEPs were recorded just before the spinal cord injury and eight days after the injury. The spinal cord ovoked potentials consisted of a small positive peak followed by a broad and high negative peak. Latencies of the maximal negative peak were measured. Nimodipine, a potent calcium antagonist with expressive effect on the central nervous system, was injectred iv. (0.1; 0.3 and 1.0 mg/kg body weight) immediately after the injury and during the eight subsequent days. In our experiment spinal cord trauma caused a latency increase of SEPs. Nimodipine diminishes mentioned alteration in spinal cord evoked potentials. The dose of 1.0 mg/kg. body weight shows the best result.
nimodipine; somatosensory evoked potentials; spinal cord injury; rabbits
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Podaci o prilogu
38-38-x.
1997.
nije evidentirano
objavljeno
Podaci o matičnoj publikaciji
Periodicum biologorum 99 (1997), suppl. 1
Vitale, Branko
Zagreb: Hrvatsko prirodoslovno društvo
Podaci o skupu
Satellite Meeting Central Nervous System : Damage and Repair
poster
11.09.1997-13.09.1997
Malinska, Hrvatska