engleski

The effect of thermodynamic factors on the precipitation of calcium oxalate monohydrate

Spontaneous precipitation of calcium oxalate monohydrate (COM) in additive-free systems with nearly the same initial supersaturation has been investigated. The influence of thermodynamic parameters such as: temperature (t = 25, 36.5 and 48 °C), calcium concentration range of 5 mmol dm−3 ≤ ci(Ca2+) ≤ 10 mmol dm−3 and pH (5.6, 6.5 and 7.5), on the potential changes in structure, morphology and crystal size of COM have been studied. The values of the initial parameters were varied in a wide range and included values relevant for mimicking the physiological conditions related to those in biological systems and kidney stone formation. The results contributed to the knowledge about the influence of the selected individual parameters as well as their interplay influence on in vitro precipitation of COM. The findings have indicated that COM was the only precipitated phase exhibiting predominant dendritic morphology. The effects on crystal size, structure and morphology are more pronounced at higher temperature, pH and calcium concentration. These results provide basis for future studies of overall mechanism of COM formation and the future studies of kidney stone prevention. Zavrsni rad je izradjen u sklopu znanstvenog rada naslova: „Precipitation of calcium oxalate monohydrate under nearly the same initial supersaturation” autora Nives Matijaković Mlinarić, Silvije Šafranko, Bernarde Vidas, Dominika Goman, Stele Jokić, Jasminke Kontrec, Branke Njegić Džakula, Ide Delač Marion, Martine Medvidović Kosanović i Anamarije Stanković objavljenog u časopisu Croatica Chemica Acta.

calcium oxalate monohydrate ; thermodynamic parameters ; crystal size and morphology ; supersaturation

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