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Synthesis and Characterization of Oxazoline Amino Acid Bioconjugates

One of the main concerns of drug development is the transfer through the cell membrane, and even further, through the nuclear membrane via protein transduction domains, a class of diverse peptides that can target intracellular proteins [1]. In our previous work it was shown that attaching metal complexes to a protein transduction domain does facilitate the transport to the cell nucleus [2]. In this communication, oxazoline amino acid bioconjugates 1-3 were prepared, containing none, one or two amino acid strands, Figure 1. The bioconjugates were characterized by NMR and IR spectroscopy and MS spectrometry. Initial synthetic studies with several inorganic or organometallic precursors will be reported. The metallated model compounds that show the best results will be chosen for further investigation with longer amino acid strands.

oxazoline ; monodenatate ; rhenium

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