Transition Metal Complexes of Dipicolylamine, Iminodiacetamide and Bis-triazole Derivatives (CROSBI ID 708504)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa
Podaci o odgovornosti
Jakopec, Silvio ; Pantalon Juraj, Natalija ; Brozovic, Anamaria ; Perić, Berislav ; Kirin, Srećko I., Raić- Malić, Silvana
engleski
Transition Metal Complexes of Dipicolylamine, Iminodiacetamide and Bis-triazole Derivatives
Ferrocene compounds have attracted significant interest as biologically active derivatives. Introduction of the ferrocene moiety in drug-like molecules improves the physicochemical properties and stability of drug candidates, while the transition metals coordinated to biologically active ligands participate in metal-specific processes which enhance drug delivery and biological activity. As part of our research of ferrocene derivatives and their transition metal complexes, we have prepared dipicolylamine, iminodiacetamide and bis-triazole derivatives connected to ferrocene through an ethylenediamine linker. The conjugates were used as ligands in the synthesis of Zn(II), Ni(II) and Cu(II) metal complexes. The stoichiometry and stereochemistry of the obtained complexes were examined by NMR and UV-Vis spectroscopy. We have obtained two crystal structures of metal complexes with bis-triazole ligands and one with an iminodiacetamide ligand. Investigation of antitumor activity is in progress.
1, 2, 3-triazole ; ferrocene ; transition metal complex
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Podaci o prilogu
177-177.
2021.
objavljeno
Podaci o matičnoj publikaciji
27HSKIKI : book of abstracts
Marković, Dean ; Meštrović, Ernest ; Namjesnik, Danijel ; Tomašić, Vesna
Zagreb: Hrvatsko kemijsko društvo
2757-0754
Podaci o skupu
27. hrvatski skup kemičara i kemijskih inženjera (27HSKIKI)
poster
05.10.2021-08.10.2021
Veli Lošinj, Hrvatska