Heterobimetallic Transition Metal Complexes of 1,2,3- Triazole Ligands (CROSBI ID 711305)
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Podaci o odgovornosti
Jakopec, Silvio ; Pantalon Juraj, Natalija ; Brozovic, Anamaria ; Gasser, Gilles ; Perić, Berislav ; Kirin, Srećko I. ; Raić-Malić, Silvana
engleski
Heterobimetallic Transition Metal Complexes of 1,2,3- Triazole Ligands
Organometallic and metal-based complexes have been widely used in drug discovery and some of them have entered clinical trials for the treatment of cancer. Design of new chemotherapy agents based on metal complexes is a fast-growing research area in which the biological activity of antitumor agents is based on metal-specific modes of action.1 The ferrocene pharmacophore is often introduced into the structure of drug-like molecules and bioactive hybrids with the aim of improvement of physicochemical properties and potency. In continuation of our research on coordination of mono- and bis-1, 2, 3-triazole derivatives, 2 we have synthesized and characterised ferrocene ligands as well as their Zn(II) and Cu(II) complexes by NMR, IR and UV-Vis spectroscopy and SC- XRD. Cytotoxic activity of N-heterocyclic ferrocene derivatives and their Zn(II) and Cu(II) complexes was evaluated.
1, 2, 3-triazole ; ferrocene ; transition metal complex
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Podaci o prilogu
4-4.
2021.
objavljeno
Podaci o matičnoj publikaciji
5th Mini Symposium of Section of Medicinal and Pharmaceutical Chemistry : Book of Abstracts
Gabelica Marković, Vesna
Zagreb: Gabelica Marković, Vesna
Podaci o skupu
5th Mini Symposium of Section of Medicinal and Pharmaceutical Chemistry
predavanje
30.11.2021-30.11.2021
Zagreb, Hrvatska