engleski

Post-Exposure Effects of Cefepime and Cefpirome on Isogenic Escherichia coli Hosts Producing SHV-Extended-Spectrum Beta-Lactamases

Persistent suppresion of bacterial growth after short antimicrobial exposure is called postantibiotic effect (PAE). By definition, there should be no subinhibitory concentrations of antimicrobial agent left when the postantibiotic effect starts. However, if subinhibitory concentrations are mantained after the antibiotic removal, the recovery period of the treated cultures is markedly prolonged. This was defined as postantibiotic-sub-MIC-effect (PA-SME). The aim of this study was to determine the postantibiotic and postantibiotic-sub-MIC effect of cefpirome and cefepime on isogenic Escherichia coli strains producing SHV-2, SHV-5, and SHV-12 extended-spectrum beta-lactamases (ESBL) compared to non-ESBL E. coli strains. It was hypothesized that the presence of an ESBL would hydrolyse the cephalosporin molecule before it exerted a toxic effect on the bacterial cell and thus shorten the duration of PA-SME.

postantibiotic effect; postantibiotic-subMIC effect; extended-spectrum beta-lactamases; cefepime; cefpirome

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