engleski

p21WAF1/CIP1 is more effective than p53 in growth suppression of mouse renal carcinoma cell line Renca in vitro and in vivo

Althouhg there are many controversial reports about the effect of p53 and p21 overexpression in different human tumor cells. the p53 gene is shown to be more effective candidate for cancer gene therapy because of its pronounced ability to induce apoptosis. In the present study, we present the effect of p53 and p21 overexpression on mouse renal carcinoma cells in vitro and in vivo. The data suggest that p21 is more potent growth suppressor than p53 of mouse tumor cells Renca. The divergent responses of tumor cells top21 overexpression could be due to various networks that differ between species.

p53; p21WAF1/CIP1; gene therapy; apoptosis; Renca cells

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