engleski

ANATOMICAL, AGE AND SEX DISTRIBUTION OF COLORECTAL CANCER IN DEPARTMENT OF PATHOLOGY CANCER REGISTRY

This study was undertaken to examine anatomical distribution of colorectal cancer, anatomical extent of disease (stage), age of presentation for different subsite locations, and whether is there any intersex difference in frequency of the disease in our Registry patient population during two years period (1998-1999). We analyzed pathological, clinical and demographic data found in our Clinical Department of Pathology Colorectal Cancer Registry. The registry was filled with data from pre-surgery and post-surgery biopsy findings in the University Hospital and clinical data both preoperative and postoperative. Colorectal cancer registry contained 540 patients with diagnosis of colorectal carcinoma. Overall female to male (F/M) ratio was 38.5%: 61.5%. The most common localization with 379 (70.2%) cases was rectosigmoid with F/M ratio 1:1.7. The next localization was descending colon with 81 (15%) cases and F/M ratio 1:1.6. In cecum and ascending colon we found 64 (11.8%) cases with F/M of 1:1. Transversal colon formed the smallest group with 16 (3%) cases and F/M ratio 1:3. There was no difference in anatomical distribution between males and females. The mean age in males was 67.3 years and in females 68.1 years. In females proximal lesions tend to present at later stage than distal, 73 years for ascending colon and 67.3 years for rectosigmoid region. This difference was not significant in males. We also analyzed TNM diagnosis in 326 patients. The most common stage was T3 with 203 (62.3%) cases. The next stage was T2 with 76 (23.3%) cases. T1 was represented in 23 (7%) cases and T4 in 24 (7.4%) cases. There was no intersex difference. The most common N stage was N0 with 166 (51%) cases, N1 was presented in 96 (29.4%), N2 in 63 (19.3%), N3 in 1 (0.3%) cases, respectively. Distant metastases were found in 14 (4.3%) cases. Sex distribution in our registry is as quoted in literature. Other parameters we analyzed (stage and age of presentation) also follow data quoted in literature. Significant difference is found in anatomical distribution of the disease. Rectosigmoid presentation of disease (70.2%) which is 2 times more common in our population. Cecum and ascending colon takes another 11.8%, which is related to data in literature 1:3.2. Transversal colon (3%) has the greatest ratio to quoted data &#8211 ; 1:6. Descending colon takes 15% and related to literature is 1.875:1.

COLORECTAL CANCER

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