engleski

Epidemiological surveillance of oral clefts in North - Western Croatia during 1983-2000 period

We present data on the registration of oral clefts in four regions of North - Western Croatia during the 1983/2000 period. The prevalence rates of oral clefts (cleft lip with or without palate - 9.1/10000 ; cleft palate - 4.6/10000) are consistent with the average prevalence rate of the EUROCAT registries (cleft lip with or without palate - 9.1/10000 ; cleft palate - 5.8/10000). We have found no significant changes in prevalence of both cleft lip with or without palate and cleft palate during the studied period. The exception is an unusually high number of cases with cleft palate that occurred in the region of Koprivnica in the year 1995. Five cases were registered, four of which were born within the period of 50 days, with closely situated places of residence. Among the total of 96 cases of the cleft lip with or without palate, we have found 78 (81.2%) isolated malformations, 17 (17.8%) cases with at least one other major malformation present, 1 syndrome, and 6 cases with chromosomal anomaly (trisomy 13). Among 52 cases of cleft palate, there were 36 (69.2%) isolated cases, 13 (25%) in association with other malformations, 3 (5.8%) syndrome cases, and 5 cases of Pierre Robin sequence. Although the presented prevalence rates of oral clefts have shown to be stable over a long time period, we consider the observation of a cluster in Koprivnica to be an important clue, which led us to analyse the influence of possible teratogenic factors.

cleft lip; cleft palate; congenital malformations; prevalence; Croatia

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