engleski

IS APOPTOSIS THE MECHANISM OF REGULATION OF THE PILOCYTIC ASTROCYTOMA SLOW GROWTH?

Aim: To examine apoptosis in 15 cases of pilocytic astrocytoma: 12 benign and 3 malignant (what is extremely rare in such tumours). There is almost no information on apoptosis in pilocytic astrocytoma in the literature. Pilocytic astrocytoma is known as a slow growth benign tumour, gradus I. Therefore we wanted to confirm if apoptosis was the mechanism of growth regulation for this tumour. Methods: The material was treated with classical paraffin procedure, hemalaun-eosin stain, cut with microtom on cuts 5 ?m thick. To determinate the volume and numerical density of apoptotic bodies the material was treated and examined stereologically with Weibel&#8217 ; s test system M42, at PF of 400x. Results: Apoptotic bodies were found neither in pilocytic astrocytoma group nor in anaplastic pilocytic astrocytoma. Conclusion: The slow growth of pilocytic astrocytoma is not regulated by mechanism of apoptosis. This is in accordance with the data shown in the literature which point out that the mutation of p53 gene, which controls the mechanism of apoptosis is not found in pilocytic astrocytoma.

PILOCYTIC ASTROCYTOMA

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