engleski

Distribution of histological carcinoma types and ages of patients with diagnosed breast cancer before and after the war agression on Croatia in 1991.

The breast cancer has lately been determined as the number one cause of cancer caused death in females of the Western regions. We recognised it as a leading mortality-morbidity issue due to data from the "Sestre Milosrdnice" University Hospital registry and National Registry for Cancer. The goal of our study was to compare histological findings and age-dependent characteristics in 578 patients with breast cancer diagnosed at the Ljudevit Jurak Clinical Department of Pathology, Zagreb ; recorded in two periods before (1980/81) and after (1997/98) the war aggression on Croatia in 1991. There were 575 women and 3 men among those patients with female to male ratio (F/M) of 191, 7. Histological type distribution in 1980 was: invasive intraductal carcinoma found in 153 (98, 7%) patients and invasive lobular carcinoma in 2 (1, 3%) patients. In 1981 there were 268 (99, 3%) intraductal carcinoma and 2 (0, 7%) lobular carcinoma. We found 69 (93, 2%) intraductal carcinomas and 5 (6, 8%) lobular in 1997 and 61 (92, 4%) intraductal carcinomas and 5 (7, 6%) lobular carcinomas in 1998. Analysis of numbers, related to early eighties and late nineties, shows a statistically significant increase of invasive lobular carcinoma from 0, 9% to 7, 1%. The average age at the time of diagnosis in 1980 was 52, 9 while in 1981 it was 54, 0. In the 1997 average age of the patients was 60, 1 and in 1998 it was 61, 5, showing a noticeable increase in average age of patients between the compared two-year periods. Conclusions given by studying changes of distribution of carcinoma types and changes of average age of diagnosis could be explained by social difficulties and stress induced by war activities in the region.

breast cancer; distribution; war

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