Aldol derivatives of 5-phenyl-1,4-benzodiazepin-2-on- N4-oxide; intriguing inertness of N-oxides in aldol reactions (CROSBI ID 101069)
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Šepac, Dragan ; Hameršak, Zdenko ; Šunjić, Vitomir
engleski
Aldol derivatives of 5-phenyl-1,4-benzodiazepin-2-on- N4-oxide; intriguing inertness of N-oxides in aldol reactions
On an attempt to prepare 3-substituted 7-chloro-1, 3- dihydro-1-methyl-5-phenyl-2H-1, 4-benzodiazepin-2-on- N4-oxides 7-10, C(3) carbanion of 5-phenyl-1, 4- benzodiazepin-2-on-N4-oxyde (2) proved completely inert in aldol reaction: Detour to the target compounds 7-10 via aldols 3-6 was required. Unexpected inertness of C(3) carbanion of 2 was attributed to the high charge delocalization.
Aldol reaction ; benzodiazepines ; carbanions ; N-oxides.
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