engleski

Is there a correlation between HER-2/NEU status and grade of the primary breast cancer?

The aim of this study was to determine the prevalence, year distribution and localisation of the skin tumours and precancerous skin lesions in the periorbital region and eyelids during the 1998-2002 period among biopsy specimens in the Ljudevit Jurak University Department of Pathology . We also analysed their relationship with sex and age of the patients. During the observed period there were total number of 286 tumors and precancerous lesions. The most common was basal cell carcinoma with slightly female prevalence. Other analysed lesions ; nevus lesions, precancerous lesions and squamous cell carcinoma were found with significantly higher female prevalence. The most frequent localisation for all lesions was on the eyelids probably as the consequence of UV irradiation. Average age for all lesions in time of diagnoses was 65 years for males and 64 years for females. All patients with skin lesions should be advised of the risk of recurrent or new tumors. Prevention remains the most important in minimising the morbidity and mortality due to lesions in this region. Exposure to ultra-violet (UV), especially UV-B, radiation is the most common cause for genetic abnormalities in cells and provoked factor in oncogenesis of skin tumors.

HER-2/NEU status; primary breast cancer

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