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Changes in the liver of BALB/c mice challanged intragastrically with Listeria monocytogenes (CROSBI ID 491552)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Bubonja, Marina ; Wraber, Branka ; Brumini, Gordana ; Dorić, Miljenko ; Abram, Maja Changes in the liver of BALB/c mice challanged intragastrically with Listeria monocytogenes // Publication of the Turkish Microbiological Society No. 44: Abstracts of Invited and Free Papers / Tumbay, Emel (ur.). Izmir: META Press, 2002. str. 63-x

Podaci o odgovornosti

Bubonja, Marina ; Wraber, Branka ; Brumini, Gordana ; Dorić, Miljenko ; Abram, Maja

engleski

Changes in the liver of BALB/c mice challanged intragastrically with Listeria monocytogenes

We studied the course of Listeria monocytogenes infection in BALB/c mice challanged intragastrically (i.g.), in an attempt to mimic natural listeriosis. The systemic infection was confirmed by positive blood cultures and a high titer of bacteria in the livers of all infected mice. However, repeated lower doses increased the severity of liver infection, resulting in a pronounced necrotizing hepatitis and extreme metabolic liver disfunction according to high levels of serum aminotransferases. During the inflammatory event, chemokine concentrations typically increased more at the local site compared to systemic level. The liver to serum ratio was most pronounced in the case of MIP-1alpha, suggesting its role in the necroinflammatory response in the liver.

Listeria; intragastric; mouse; liver

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Podaci o prilogu

63-x.

2002.

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objavljeno

Podaci o matičnoj publikaciji

Publication of the Turkish Microbiological Society No. 44: Abstracts of Invited and Free Papers

Tumbay, Emel

Izmir: META Press

Podaci o skupu

FEMS Symposium: The Versatility of Listeria Species

poster

10.10.2002-11.10.2002

İzmir, Turska

Povezanost rada

Temeljne medicinske znanosti