Changes in the liver of BALB/c mice challanged intragastrically with Listeria monocytogenes (CROSBI ID 491552)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Bubonja, Marina ; Wraber, Branka ; Brumini, Gordana ; Dorić, Miljenko ; Abram, Maja
engleski
Changes in the liver of BALB/c mice challanged intragastrically with Listeria monocytogenes
We studied the course of Listeria monocytogenes infection in BALB/c mice challanged intragastrically (i.g.), in an attempt to mimic natural listeriosis. The systemic infection was confirmed by positive blood cultures and a high titer of bacteria in the livers of all infected mice. However, repeated lower doses increased the severity of liver infection, resulting in a pronounced necrotizing hepatitis and extreme metabolic liver disfunction according to high levels of serum aminotransferases. During the inflammatory event, chemokine concentrations typically increased more at the local site compared to systemic level. The liver to serum ratio was most pronounced in the case of MIP-1alpha, suggesting its role in the necroinflammatory response in the liver.
Listeria; intragastric; mouse; liver
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Podaci o prilogu
63-x.
2002.
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objavljeno
Podaci o matičnoj publikaciji
Publication of the Turkish Microbiological Society No. 44: Abstracts of Invited and Free Papers
Tumbay, Emel
Izmir: META Press
Podaci o skupu
FEMS Symposium: The Versatility of Listeria Species
poster
10.10.2002-11.10.2002
İzmir, Turska