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Increased bone mass is a part of the generalized lymphoproliferative disorder phenotype in the mouse (CROSBI ID 101477)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Katavić, Vedran ; Lukić, Ivan Krešimir ; Kovačić, Nataša ; Grčević, Danka ; Lorenzo, Joseph ; Marušić, Ana Increased bone mass is a part of the generalized lymphoproliferative disorder phenotype in the mouse // Journal of immunology, 170 (2003), 3; 1540-1547-x

Podaci o odgovornosti

Katavić, Vedran ; Lukić, Ivan Krešimir ; Kovačić, Nataša ; Grčević, Danka ; Lorenzo, Joseph ; Marušić, Ana

engleski

Increased bone mass is a part of the generalized lymphoproliferative disorder phenotype in the mouse

We investigated the bone phenotype of mice with generalized lymphoproliferative disorder (gld) due to a defect in the Fas ligand-mediated apoptotic pathway. C57BL/6-gld mice had greater whole body bone mineral density and greater trabecular bone volume than their wild-type controls. gld mice lost 5-fold less trabecular bone and had less osteoclasts on bone surfaces after ovariectomy-induced bone resorption. They also formed more bone in a model of osteogenic regeneration after bone marrow ablation, had less osteoclasts on bone surfaces and less apoptotic osteoblasts. gld and wild-type mice had similar numbers of osteoclasts in bone marrow cultures, but marrow stromal fibroblasts from gld mice formed more alkaline phosphatase-positive colonies. Bone diaphyseal shafts and bone marrow stromal fibroblasts produced more osteoprotegerin mRNA and protein than wild-type mice. These findings provide evidence that the disturbance of the bone system is a part of generalized lymphoproliferative syndrome and indicates the possible role of osteoprotegerin as a regulatory link between the bone and immune system.

bone; bone marrow; cytokines

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Podaci o izdanju

170 (3)

2003.

1540-1547-x

objavljeno

0022-1767

Povezanost rada

Temeljne medicinske znanosti, Kliničke medicinske znanosti

Indeksiranost