engleski

Use of midazolam in puncture of bone marrow in children oncologic patients

Diagnostic punctures in children oncologic patients, along with therapeutic procedures are additional stress during hospitalization. Use od analgetics by local anaesthetic is acceptable in punctures of cutaneous and subcutaneous tissue, and partly in diagnostic lumbal punctures. Use of benzodiazepin for sedation is not appropriate- children suffer pain regardless of sedative. Drawbacks of general anaesthesia are known although there is no pain suffering for a patient. Midazolam is a hypotonic used in introduction to anaesthesia. Used parenterally, it enable a break of brain activities in a shorter period, enoug for conduction of diagnostic puncture. At Oncologic ward of Children's hospital- Zagreb, there were 212 punctures conducted in 1994. of which 81 were sternal. We applied Midazolam in40 patients- 22 girls and 18 boy - aged 2-16 .The patients' diagnosis were: Sarcoma Ewing, Neuroblastoma, non- Hodgkinlymphoma. A dose of drug was 0,3 mg/kg. Midozolam was applied i.v. in 7 patients and by CVK in 33 patients. We followed -up behaving of patients during application of the drug, later amnesia and conditions for application of midazolam in repeated sternal puncture.

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