engleski

Oxidative stress in diabetic patients with and without peripheral vascular disease.

Background and Aims: The aim of this study was to compare antioxidative status in diabetic and non-diabctic patients, as weil as to compare antioxidative status in diabelic patients with and without peripheral vascular disease. Materials and Methods: Our study included 211 participants, from which 109 were diabetics patients. Diabetic patients were subdivided inlo 2 groups: with peripheral vascular disease (DM+PVD+) and without peripheral vascular disease (DM+PVD-). Diagnosis of peripheral vascular disease has been established by Doppler sonographic analysis. Antioxidative status has been presented through establishing key antioxidative enzimes: superoxide dismutase (SOD), catalase, glutalhion peroKidase (GLPX), total antioxidative status (TAS) by Randox tesls RANSLE and RANSOD. The participants have been examined and the key parameters have been estabiished: weight, hight, BM1, age, lype of diabetes, dala about thc lenght of diabetes, smoking, art. hypertension, as well as Doppler sonography of peripheral arteries, ECG, antioxydative status, lipid prophile, fibrinogen, glucosis, HbAlC, biurct. The participants have also been asked about history of CAD, stroke and diabetic retinopathy. The statistical analysis was performed using Mann-Whitney lest. Results: Diabetic patients had mean rang of TAS 83.06, whereas non-diabetic patients had mean rang of TAS 130.51 (p=0.000). Diabetic patients had mean rang of SOD 122.56, whereas non-diabetic patients had mean rang of SOD 88.31 (p=0.000). Diabetic patients had mean rang of catalase 95.22, whereas non-diabetic patients had mean rang of catalase 117.52 (p=0.001). Diabetic patients had mean rang of GLPX 84.29, whereas non-diabetic patients had mean rang of GLPX 129.20 (p=0.000). DM+PVD+ group had mean range of TAS 54.01, whereas DM+PVD- group had mean range 55.94 (p=0.750). DM+PVD+ group had mean range of SOD 56.82, whereas DM+PVD- group had mean range 53, 28 (p=0.555). DM+PVD+ group had mean range of catalase 62.59, whereas DM+PVD- group had mean range 47.81 (p=0.015). DM+PVD+ group had mean range of GLPX 53.68, whereas DM+PVD- group had mean range 56.25 (p=0.676). Conclusions: Our study has shown the statistically significanl lower activity of antkmdative enzimes in diabetic patients in comparison 10 non-diabelic patients. We demonstrated the presence of oxidative stress through statistically significant antioxidative status disbalance irrespcctive of the presence of peripheral vascular disease, which underlines his major role in pathogenesis of vascular complications in DM, prior to clinical manifestation.

antioxidative status in diabelic patients with and without peripheral vascular disease.

nije evidentirano