engleski

Phenotypic characterization of human first trimester decidua macrophages

About 15-20% of bone marrow derived cells in the endometrium and the decidua are CD14-positive macrophages coexpressing the scavenger receptor CD163. The costimulatory molecule CD86 (B7-2) but not CD80 (B7-1) is found expressed on first trimester and term decidua macrophages (D-Mph). The number of D-Mph increases at the implantation site in the basal decidua, where they are in contact with the HLA-G-positive invading extravillous cytotrophoblast. As D-Mph express the inhibitory receptors CD85d (ILT4, LIR-2) and CD85e (ILT2, LIR-1), they are potentially susceptible to inhibition by class Ia and class Ib molecules. D-Mph may have specific functions relating to successful pregnancy, and phenotypic and functional properties may differ between early and term pregnancy. A number of data make their molecular repertoire comparable to those of alternatively activated macrophages which are immunosuppressive for Th1 cells: First trimester decidua macrophages express IL-10 and the MS-1 high molecular weight antigen and the coagulation Factor XIIIa is detectable in the cytoplasm. Functional data are required to complement these studies.

Decidua; Macrophage; CD85d; CD85e; MS-1; Activation

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