engleski

Electrical circuit analogy for enzymatic cycle kinetics

A free-energy transducing macromolecule, interacting with ligands, and cycling through discrete states, can be described by the Hill's diagram. Close to equilibrium, where linear flčux-force relationship hold, we develop a method of the construction of the electrical circuit corresponding to the Hill's diagram. The Thevenin's theorem is used to find the efficiency of free-energy transduction. Maximal power transfer conditions are then found too. The method of the mesh currents is used to give an alternate, much more elegant proof of the Jean's theorem from 1923. Assuming fixed ligand concentrations, we prove by means of the Jean's theorem, that fluxes in the steady state enzymatic cycle kinetics, distribute themselves to make the entropy production maximal.

free-energy transduction; enzymatic kinetics; electrical circuit analogy

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