engleski

Is there a correlation between HER-2/neu status and grade of the primary breast cancer?

HER-2/neu amplification is a marker of poor prognosis in breast cancer. Patients whose tumors show overexpression of HER-2/neu have shortened disease-free and overall survival. The aim of this study was to determinate immunohistochemistry HER-2/neu overexpression in 121 cases of primary breast cancer. In addition HER-2/neu status was correlated with hormone receptor status, grades and pTNM stage. The both groups of HER-2/neu negative and HER-2/neu positive patients were average ages of about 60 years. In all the HER-2/neu groups (negative, 1+, 2+ and 3+) estrogen and progesterone receptor were highly positive in a high percentage of cases. Also in both groups of HER-2/neu negative and HER-2/neu positive invasive ductal carcinoma the most common grades were 2, but in HER-2/neu 3+ group, there were also 30.0% of cases having grade 3. Our results show that there might be a correlation between HER-2/neu overexpression and higher grade of breast cancer. The two most common pTNM stages were T1N0MX and T2N1MX. HER-2/neu receptor is important therapeutic target and testing for HER-2/neu status is now recommended as a part of routine breast cancer diagnosis. The role of new biomarkers, such as HER2/neu and clinical value of its determination must be provided by prospective clinical studies.

breast cancer; HER-2/neu; prognostic value

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