Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Entrapment of peptidoglycans and adamantyltripeptides into liposomes : an HPLC assay for determination of encapsulation efficiency (CROSBI ID 101969)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Frkanec, Ruža ; Travaš, Dijana ; Krstanović, Marina ; Halassy Špoljar, Beata ; Ljevaković, Đurđica ; Vranešić, Branka ; Frkanec, Leo ; Tomašić, Jelka Entrapment of peptidoglycans and adamantyltripeptides into liposomes : an HPLC assay for determination of encapsulation efficiency // Journal of liposome research, 13 (2003), 3&4; 279-296. doi: 10.1081/LPR-120026452

Podaci o odgovornosti

Frkanec, Ruža ; Travaš, Dijana ; Krstanović, Marina ; Halassy Špoljar, Beata ; Ljevaković, Đurđica ; Vranešić, Branka ; Frkanec, Leo ; Tomašić, Jelka

engleski

Entrapment of peptidoglycans and adamantyltripeptides into liposomes : an HPLC assay for determination of encapsulation efficiency

The encapsulation of different immunomodulating peptides, the peptidoglycan monomer, its semisynthetic derivatives (Adamant-1-yl)-acetyl-peptidoglycan monomer and Boc-Tyr-peptidoglycan monomer, respectively, and of two diastereoisomers of adamantyltripeptides into the large negatively charged multilamellar liposomes was investigated. The reproducible quantitative method using HPLC was established for the determination of the entrapped compounds. It was shown that the tested compounds could be efficiently incorporated into liposomes using either the film or modified film method. The results confirmed that the peptidoglycans with lipophilic supstituents and particularly the adamantyltripeptides were incorporated into liposomes with higher efficiency than the peptidoglycan monomer using either of the described methods. Liposome preparations were stable at 4 °C up to seven days as shown by minimal leaking of the entrapped material.

peptidoglycan monomer; adamantyltripeptides; liposomes; HPLC; encapsulation

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

13 (3&4)

2003.

279-296

objavljeno

0898-2104

10.1081/LPR-120026452

Povezanost rada

Kemija, Temeljne medicinske znanosti, Biologija

Poveznice
Indeksiranost