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Synthesis, Characterization And Antiproliferative Activity Of Coumarin-based Metal Complexes

Cancer is the second leading cause of death worldwide, resulting in around 9 million deaths annually [1]. Among the approved anticancer drugs, around 80% of them are derived from natural compounds. Coumarin derivatives are ubiquitous in nature and can readily interact with a variety of enzymes and receptors such as kinase, telomerase, aromatase, sulfatase, monocarboxylate transporters, and carbonic anhydrase, thereby exhibiting a potential activity against various cancer cell lines including multidrug‐resistant cells [24]. Thus, the coumarin moiety is a useful template for the development of novel anticancer agents. On the other hand, metal-based drugs have gained attention to address the negative aspects of platinum-based drugs, like high toxicity, resistance to treatment, low specificity for target DNA, and poor absorption [5]. Considering the promising anticancer activity of metal complexes, we designed and synthesized coumarin– pyridine hybrids and their metal complexes with the aim to evaluate their antiproliferative activity (Fig. 1). Herein, we report syntheses, spectroscopic characterization and anticancer activity of coumarin ligands and their Ru(II) and Re(I) complexes. References [1] A. Kopacz-Bednarska, T. Król, Oncol. Clin. Pract. 18 (2022) 166176. [2] T. Gazivoda Kraljević, A. Harej, M. Sedić, S. Kraljević Pavelić, Višnja Stepanić, D. Drenjančević, J. Talapko, S. Raić-Malić, Eur. J. Med. Chem. 124 (2016) 794808. [3] I. Sokol, M. Toma, M. Krnić, A. Meščić Macan, D. Drenjančević, S. Liekens, S. Raić- Malić, T. Gazivoda Kraljević, Future Med. Chem. 13 (2021) 18651884. [4] A. Bistrović, N. Stipaničev, T. Opačak- Bernardi, M. Jukić, S. Martinez, Lj. Glavaš- Obrovac, S. Raić-Malić, New J. Chem. 41 (2017) 75317543. [5] S. Jakopec, N. Pantalon Juraj, A. Brozovic, D. Jadreško, B. Perić, S. I. Kirin, S. Raić-Malić, Appl. Organomet. Chem. 36 (2022) e6575.

coumarine, rhenium complexes, antitumor activity

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