engleski

Analysis of individual antibodies to HCV in HCVAg positive individuals

Following the dynamics of appearing and disappearing of HCVAg in some of our patients with acute HCV infection we found simultaneous presence of HCVAg and anti-HCV mainly in a period when HCVAg were near disappearance (group 1). Beside that we found a simultaneous presence of HCVAg and anti-HCV in a number of patients with long persistence of anti-HCV (group 2). In the majority of cases with simultaneous presence of HCVAg and anti-HCV, spectrum of individual antibodies differed from that found in individuals with anti-HCV only (without HCVAg). We tried to analyse spectrum of individual antibodies to HCVAg in group 1 and 2 in more detail. A total of 45 sera 15 from group 1 and 30 from group 2 with simultaneous presence of HCVAg and anti-HCV were tested for individual antibodies to HCV.Control group comprised 50 sera of 50 patients without HCVAg and anti-HCV only.Anti-HCV: c100(p) were present in 61, 5% in group 1 and in 63, 2% in group 2 vs 100, 0% in control group ; c33c-100, 0%(group 1), 100, 0%(group 2), 98, 7% (control) ; c22(p)-45, 2% (group 1), 51, 8% (group 2), 100, 0% (control) ; NS5-33, 1% (group 1), 49, 7% (group 2), 95, 8% (control). These findings showed that spectrum of individual antibodies to HCVAg in both groups of patients with simultaneous presence of HCVAg and anti-HCV (acute HCV infection and individuals with long lasting HCV positivity) is more narrow than in control group (with anti-HCV but without HCVAg). Possible explanation for such differencies could be that slow appearance of some antibodies in the acute HCV infection (due to evolution of antibodies) enables detection of HCVAg for yet some period of time and disappearance of the same antibodies after a lng persistence directed to some HCVAg epitopes enables "reappearance" of HCVAg simultaneously with anti-HCV.

Individual antibodies; HCVAg

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