MCMV glycoprotein gp40 confers virus resistance to CD8+ T cells and NK cells in vivo (CROSBI ID 493631)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Krmpotić, Astrid ; Busch, Dirk ; Bubić, Ivan ; Gebhardt, Friedemann ; Hengel, Hartmut ; Hasan, Milena ; Scalzo, Anthony ; Koszinowski, Ulrich ; Jonjić, Stipan
engleski
MCMV glycoprotein gp40 confers virus resistance to CD8+ T cells and NK cells in vivo
The susceptibility of certain inbred mouse strains to MCMV is related to their inability to generate a strong NK cell response. We addressed here whether the MCMV susceptibility of the BALB/c strain is due to viral functions that control NK cell activation in a strains-specific manner. MCMV expresses two proteins, gp48, and gp40, that are encoded by the genes m06 and m152, respectively ; they down-regulate MHC class-I expression at the plasma membrane. Using MCMV deletion mutants and revertants we found that gp40 but nor gp48 controls NK cell activation. Absence of gp40 improved antiviral NK cell control in BALB/c but not C57BL/6 mice. Down-regulation of H60, the high affinity ligand for the NKG2D recepotr, was the mechanism by which gp40 modulates NK cell activation. Thus, a single herpesvirus protein has a dual function in inhibiting both, the adaptive as well as the innate immune response.
MCMV; m152; NK cells; NKG2D
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Podaci o prilogu
41-x.
2002.
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objavljeno
Podaci o matičnoj publikaciji
Annual Meeting of Croatian Immunological Society, Trakošćan, Croatia
Jonjić, Stipan
Rijeka:
Podaci o skupu
Annual meeting of the Croatian Immunological Society 2002
poster
22.11.2002-24.11.2002
Trakošćan, Hrvatska