engleski

Successful treatment of childhood acute lymphatic leukemia

Children *86( with acute lymphatic leukemia ALL were treated with protocol ALL BFM 90 at the Centre for the Treatment of Leukaemia in Children, Department of Hematology and Oncology, Pediatric Clinic, {alata, University Hospital in yagreb, from 1st June 1992 to first June 1997. The results of treatment were analysed. The first complete remission was achieved in 86 100% / 33 day, in 71 83% / 15 daz. The first relapse occured in 12 14% patients / 9 hematologic relapse, 1 meningeal relapse, 2 hematologic et meningeal relapse. After a median observation time of 22 months, the overal probability for eventfree survival p/EFS is 81 =2%. 14 patients /16% died / 12 during relapse and 2 for other reasons. At this time p/EFS for each strategic group is 87 = 3% for SRG, 86 = 2% for MRG and 41 = 5% for HRG. These preliminary results indicate that for 89% of ALL patients risk adapted intensive therapy can provide a high chance for cure, Interestingly patients with more than 20% blasts in the bone marrow at day 15 suffer twice as many relapses as those with 5/20%, and four times more than those with less than 5% blasts.

treatment; lymphatic leukemia; children

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