engleski

Genetic variation at nine short tandem repeat loci in the Croatian populations

The aim of this study is to analyze genetic variation at nine autosomal short tandem repeat loci (D3S1358, vWA, FGA, THO1, TPOX, CSF1PO, D5S818, D13S317, D7S820) in six populations from Croatia, five of which are distributed in the islands of the eastern Adriatic coast and one is drawn from the mainland. The purpose is to investigate genetic structure of the Croatian populations and to evaluate the usefulness of the studied loci in regional level genetic differentiation. This investigation demonstrates a substantial genetic homogeneity of the Croatian gene pool as revealed by distribution of allelic frequencies, heterozygosity values, number of alleles and allele size variance, allele and genotype sharing data and the coefficient of gene differentiation. Even though a larger sample sizes for villages within islands could have provided a greater power of autosomal STRs in resolving patterns of microevolutionary structuring at regional level, the greatest discriminating power will certainly result when all classes of genetic markers, paternal, maternal and autosomal, will be jointly considered.

Autosomal STRs; Population data; Croatia

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