engleski

Y chromosome haplotype diversity in insular and mainland populations from Croatia

Y chromosome haplotypes have become invaluable tools for determination of parentage and kinship in forensic casework and population genetics. Eight short tandem repeat (STR) polymorphic systems mapped on the human Y chromosome (DYS19, DYS388, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393) were typed in mainland (n = 109) and four insular (n = 348) populations. A general allelic frequency distribution in the overall Croatian sample corresponds to other European populations with the exception of the loci DYS19 and DYS389II. The most frequent DYS19 allele was 16, while at the DYS389II the most frequent were alleles 30 and 31. Complete typing was obtained for 457 chromosomes that showed two hundred forty one different Y chromosome haplotypes. The most frequent Y chromosome haplotype (16-13-13-31-24-11-11-13) was found in 33 individuals (7.22%). One hundred seventy four haplotypes (38.07%) were observed in single copies. Comparison of insular and mainland populations showed a statistically significant difference in allele frequencies at 4 out of 8 loci. Moreover, the haplotype 16-13-13-32-24-11-11-13 was noticed exclusively in two islands. The haplotype diversity ranged from 0.9749 (island of Korcula) to 0.9913 (mainland). Observed differences between mainland and insular populations could be explained by specific population histories, unlike settling patterns involving different gene boundaries and more pronounced effects of genetic drift in islands.

Y chromosome STRs; haplotypes; Croatia

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