Mathematical Model of B-Cell CLL (CROSBI ID 495714)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Martinis, Mladen ; Vitale, Branko ; Zlatić, Vinko
engleski
Mathematical Model of B-Cell CLL
Chronic lymphocytic leukemia (CLL) is defined as a disorder of morphologically mature but immunologically less mature lymphocytes which is manifested by uncontrolled expansion of a single clone of B-cells that did not retain capacity to differentiate into functionally mature cells and activate the programmed cell death. Many aspects of the interaction and/or communication between B- and T-cells in CLL can be understood by examining simple nonlinear dynamical models. The significance of these models is their prognostic ability to predict, from a given initial data, the time course leading to low- or high-risk pathways of CLL.In this respect, we propose a nonlinear mathematical model of B-CLL pathogenesis in which B- CLL is considered as a clinical disorder which simultaneously affects both B-cells and T-cells on the intercellular communication level. Our dynamical model deals with a profound quantitative imbalance between expanded CD5+ME+ clone of leukemic B-cells, and only slightly increased absolute number of helper CD4+ T-cells accompanied by eight to tenfold increase of the absolute number of cytotoxic/suppressor CD8+ T- cells resulting in the inversion of the DC4/DC8 ratio to less than one in comparison with healthy subjects.The dynamics of these two active groups of cells is described by the generalized Volterra type equations.
leukemia; lymphocities; B-cells
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
112-112-x.
2003.
objavljeno
Podaci o matičnoj publikaciji
Liječnički vjesnik 125, Supl. 3, 2003
Čikeš, Nada
Zagreb: Hrvatski liječnički zbor
Podaci o skupu
3. hrvatski kongres hematologa i transfuziologa s međunarodnim sudjelovanjem
predavanje
23.10.2003-26.10.2003
Zagreb, Hrvatska