engleski

Tree years follow up of young women presenting positive high risk HPV (16, 18) and low-grade intraepithelial lesion of cervix

Objectives: Well known risk factors for cervical cancer are early onset of sexual activity, multiple sexual partners, lower socio-economic groups, hystory of STD in patient or their partners. Possible or minor risk factor is smoking. HPVinfection of cervics has been found as mayor risk and trigger factor for development of cervical intraepithelial lesions. Methods: Three years follow up of cervical smears in two groups of patients ; I group of 30 women between 18 and 29 years, nonsmokers or quit smoking, condom users, monogamous relations, treated for all coexisting infections of cervics with qaterly Pap smear, and II group of 30 women between 18 and 30 years, smokers, with multiple sexual partners, sporadic condom users with no treatement for cervical coinfections, only annual smear. The first smear in all patients indicated first time ever low-SIL with positive high risk HPV infection proved by Digene Hybride capture II sistem. They were all offered written information about HPV infection as a STD. The task of the study was to indicate the rates of progression, regression and persistency of smear results. Results: In group I we found regression of cervical smear results in 16, 6 % (5/30), progression to high-grade SIL in 10% (3/30), and persistency in 73, 4 % (28/30). In group II there were no regression, 70 % (21/30) of patients had progression in following smears, and persistent smears only in 9 patients-30%. All patients with high-grade SIL had cold knife conisation. Conclusion: The study shows that those patients (group I) who had followed given instructions about their hisks and proposed sexual behaviour and were eager to erradicate coexisting infections had progression of lesion only in 10 %. Patients who did not follow these instuctions, and did not erradicate coexisting infections of cervics in 70 % end up at conisation. Therefore we conclude: education about sexual behaviour and habits of young women, motivation for therapy of coexisting STDs, regular Pap smear controls and HPV typisation in even low-grade SIL lesions are crucial to minimize all risks factors and their potentials for development and progression of cervical intraepithelial lesions.

HVP; intraeipthelial lesion; cervic

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