engleski

Inhibitory Effect of Water-Soluble Derivative of Propolis and Its Polyphenolic Compounds on Tumor Growth and Metastasizing Ability: A Possible Mode of Antitumor Action

Polyphenolic compounds are widely distributed in the plant kingdom, and display a variety of biological activities, including chemoprevention and tumor growth inhibition. Propolis is made up of a variety of polyphenolic compounds. We compared how the route of administration of polyphenolic compounds deriving from propolis and propolis itself affects the growth and metastatic potential of a transpatable mammary carcinoma (MCa) of CBA mouse. In addition, the influence of tested compounds on local tumor growth was also studied. Metastases in the lung were generated by 2x105 tumor cells injected iv. A water-soluble derivative of proplis (WSDP) and polyphenolic compounds (caffeic acid-CA and caffeic acid phenethyl ester-CAPE) were given to mice po or ip before or after tumor cells inoculation. Tested compounds significantly decreased the number of lung colonies. When mice were inoculated with 105 mammary carcinoma cells in the exact site of subcutaneous injection of different doses of WSDP, CA or CAPE, tumor growth was inhibited and survival of treated mice was prolonged. Antitumor activity, according to the results obtained, is mostly related to the immunomodulatory properties of the compounds and their capacity to induce apoptosis and necrosis. In conclusion, results presented here indicate that WSDP, CA, and CAPE could be a potential useful tool in the control of tumor growth in experimental tumor models when administrated perorally ; since po administration is the easiest way of introduction of a compound used for prevention and/or cure of any disease it is likely that this paper reached the aim of the investigation.

propolis ; tumor ; metastases

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