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Peripheral biochemical markers in Alzheimer's disease (CROSBI ID 496365)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija

Pivac, Nela ; Muck-Šeler, Dorotea ; Mimica, Ninoslav ; Mustapić, Maja ; Šagud, Marina ; Folnegović-Šmalc, Vera ; Mihaljević-Peleš, Alma ; Jakovljević, Miro Peripheral biochemical markers in Alzheimer's disease // European psychiatry / Ferrero, Francois ; Maj, Mario ; Sartorius, Norman (ur.). 2004. str. 152s-152s

Podaci o odgovornosti

Pivac, Nela ; Muck-Šeler, Dorotea ; Mimica, Ninoslav ; Mustapić, Maja ; Šagud, Marina ; Folnegović-Šmalc, Vera ; Mihaljević-Peleš, Alma ; Jakovljević, Miro

engleski

Peripheral biochemical markers in Alzheimer's disease

Peripheral biochemical abnormalities are associated with Alzheimer's disease (AD). The aim of the study was to elucidate platelet serotonin (5-HT) concentration, platelet monoamine oxidase (MAO) activity, plasma cortisol, prolactin, and plasma lipid levels (cholesterol, triglycerides, low and high density lipoproteins) in drug-free AD patients and healthy subjects. The diagnosis of the probable AD according to NINCDS-ADRDA criteria was established by two psychiatrists according to ICD-10 and DSM-IV-TR criteria. In 34 patients with AD (14 men ; 20 women) and sex and 75 age-matched healthy controls (36 men ; 39 women) platelet 5-HT concentration and platelet MAO activity were determined spectrofluorimetrically, while plasma levels of cortisol and prolactin were determined by a radioimmunoassay, and plasma lipids by a standard laboratory procedures. All participants gave their informed consent. Data, expressed as means ± ; ; ; SD, were evaluated using one-way analysis of variance followed by Tukey's test. Patients with AD had significantly higher platelet 5-HT concentration and platelet MAO activity than healthy subjects, and similar values of plasma cortisol, prolactin and plasma lipid levels as healthy controls. Significantly higher platelet 5-HT values were found in female AD patients than in control women, while platelet MAO activity was increased in male and female AD patients when compared to corresponding controls. The results from our preliminary, ongoing study, support the presumption that alterations in platelet serotonergic (5-HT and MAO), but not in other peripheral biochemical (plasma cortisol, prolactin and lipids) markers are associated with AD.

platelet serotonin and monoamine oxidase; plasma cortisol; prolactin and lipids; Alzheimer's disease

doi:10.1016/j.eurpsy.2004.01.008 ; http://dx.doi.org/10.1016/j.eurpsy.2004.01.008

nije evidentirano

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Podaci o prilogu

152s-152s.

2004.

nije evidentirano

objavljeno

Podaci o matičnoj publikaciji

European psychiatry

Ferrero, Francois ; Maj, Mario ; Sartorius, Norman

Amsterdam: Elsevier

0924-9338

Podaci o skupu

Association of European Psychiatrists Congress (12 ; 2004)

poster

14.04.2004-18.04.2004

Ženeva, Švicarska

Povezanost rada

Temeljne tehničke znanosti, Temeljne medicinske znanosti

Indeksiranost