engleski

Influence of honey bee products on transplantable murine tumors

The effect of the propolis, honey, royal jelly and bee venom on tumor growth, metastazing ability and induction of apoptosis and necrosis in murine tumor models (mammary carcinoma and colon carcinoma) was investigated. Water soluble- derivate of propolis (WSDP) and related polyphenolic compounds showed significant anti-metastatic effect given either before or after tumor-cell inoculation. Oral or systemic application of WSDP or caffeic acid significantly reduced subcutaneous tumor growth and prolonged the survival of mice. Honey also exerted pronounced anti-metastatic effect when applied before tumor-cell inoculation. Royal jelly did not affect metastasis formation when given intraperitoneally or subcutaneously. However, intravenous administration of royal jelly before tumor-cell inoculation significantly inhibited metastasis formation. When mice were given 10 5 tumor-cells intravenously immediatly after bee venom injection, the number of tumor nodules in the lung was significantly lower than in untreated mice or mice treated with bee venom subcutaneously. Local presence of bee venom in tissue caused significant delay in subcutaneous tumor formation. Local presence of bee venom are highly dependent on the route of injection and on close contact between components of the bee venom and tumour cells.

apoptosis and necrosis; honey bee products; metastasis; tumors

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