engleski

The significance of Malassezia furfur in etiopathogenesis of atopic dermatitis

The aim of the study was to determine the significance of M. furfur in the etiopathogenesis of atopic dermatitis. The study included 50 patients with atopic dermatitis, 50 patients with seborrheic dermatitis and 30 helathy exminess as a control group. Immediate and contact hypersensitivity were determined by skin prick test and patch test, which were carried out with water-soluble extract of M. furfur (protein conentration og 5 mg/mL). Skin prick test to M. Furfur was positive in 27 of 50 patients with atopic dermatitis, 9 of 50 patients with seborrheic dermatitis, and only in a single healthy control subject. Positive reaction to patch test to M. furfur were observed in 7 patients with atopic dermatitis and none of the patients with seborrheic dermatitis and healthy controls. Positive reaction to skin prick test were significantly more frequent among patients with atopic dermatitis than in the other two groups of examinees (p<0.05) ; the same result was obtained for patch test results. Present study proved the role od immediate and contact hypersensitivity to M. furfur in exacerbation of atopic dermatitis but not in seborrheic dermatitis.

Malassezia furfur; atopic dermatitis; contact hypersensitivity; skin prick test

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