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New bone induction by demineralized bone matrix in immunosuppressed rats (CROSBI ID 105823)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Marušić, Ana ; Đikić, Ivan ; Vukičević, Slobodan ; Marušić, Matko New bone induction by demineralized bone matrix in immunosuppressed rats // Experientia, 48 (1992), 783-785

Podaci o odgovornosti

Marušić, Ana ; Đikić, Ivan ; Vukičević, Slobodan ; Marušić, Matko

engleski

New bone induction by demineralized bone matrix in immunosuppressed rats

Subcutaneous implantation of demineralized bone matrix (DBM) initiates a sequence of developmental events which culminate in endochondral bone formation.To test the effects of T-cell deficiency on new bone formation, the morphology of DBM- induced bone was examined in rats thymectomized at three weeks of age and in thymectomized or nonthymectomized rats lethally irradiated and reconstituted with syngenic bone marrow.At 24 days after implantation, bone induction in control rats was appropriate for their age, while thymectomized-irradiated- reconstituted rats and thymectomized rats had significantly more new bone and larger bone marrow space than the controls.In non-thymectomized, irradiated and reconstituted rats, bone induction occurred in only 25% of the animals, compared to 95% in other groups.

Bone matrix ; Osteoinduction ; Thymectomy ; Irradiation ; Bone marrow reconstitution ; Immunosuppression

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Podaci o izdanju

48

1992.

783-785

objavljeno

0014-4754

Povezanost rada

Temeljne medicinske znanosti

Indeksiranost