New bone induction by demineralized bone matrix in immunosuppressed rats (CROSBI ID 105823)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Marušić, Ana ; Đikić, Ivan ; Vukičević, Slobodan ; Marušić, Matko
engleski
New bone induction by demineralized bone matrix in immunosuppressed rats
Subcutaneous implantation of demineralized bone matrix (DBM) initiates a sequence of developmental events which culminate in endochondral bone formation.To test the effects of T-cell deficiency on new bone formation, the morphology of DBM- induced bone was examined in rats thymectomized at three weeks of age and in thymectomized or nonthymectomized rats lethally irradiated and reconstituted with syngenic bone marrow.At 24 days after implantation, bone induction in control rats was appropriate for their age, while thymectomized-irradiated- reconstituted rats and thymectomized rats had significantly more new bone and larger bone marrow space than the controls.In non-thymectomized, irradiated and reconstituted rats, bone induction occurred in only 25% of the animals, compared to 95% in other groups.
Bone matrix ; Osteoinduction ; Thymectomy ; Irradiation ; Bone marrow reconstitution ; Immunosuppression
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Podaci o izdanju
Povezanost rada
Temeljne medicinske znanosti