engleski

Immunosuppression induced by talc-granulomatosis in the rat

Apart from the bone loss, talc granulomatosis induces profound alterations of the immune system in the rat. The disturbance includes zhe reduction of mononuclear white blood cells count in the peripheral blood, atrophy of the thymic cortex, spleen enlargement with macrophage sheet hypertrophy, lymph node germinal center blurring and a significant delay on the first and second- set allograft rejection. Indomethacin suppression of prostaglandin production did not normalize the allograft rejection dynamics.In contrast, splenectomy completely abolished the immunosuppressive effects of granulomatosis. Suppression of immune response to alloantigens was transferred to normal and splenectomized recipients by both serum and spleen cells of talc- injected animals. Also, in a cell-mixture-transfer experiment, spleen cells from talc-granulomatosis- bearing donors suppressed the immune response induced by lymph node cells from immune donors in T-cell-deficient rats. The inability of serum from splenectomized talc-injected rats to transfer the suppression suggested the crucial role of the spleen in the mechanisms leading to suppression in rats bearing talc-granulomas. The possible relationship between the bone and immunological changes is currently under investigation.

talc granulomatosis

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