engleski

The importance of vitamin D3 for the development of the acute phase response and bone changes in rats with talc-induced inflammation

Subcutaneous inflammation provoked by talc causes decreased formation and function of osteoblasts and subsequent bone loss in the rat. To ascertain the possible role of vitamin D3 in the pathogenesis of the bone loss, second generation of rachitic rats was injected sc with the talc suspension. Bone histologic and serum biochemical analyses were performed three and seven days after talc injection. In the mataphyses of the rachitic, talc-injected rats, no histological evidence of the osteoblast insufficiency and bone loss could be observed. Serum osteocalcin was decreased in normal talc-injected rats, and unchanged in rachitic rats with talc granulomas. Both normal and rachitic talc-injected rats developed the acute phase response, evidenced as low Zn and high Cu serum levels, except for the change in the serum Fe. Both talc-injected groups had very high ACTH serum values. Talc injection caused severe hypermagnesiemia in the rachitic rats, whereas in normal rats it had no influence on the serum Mg. Rachitic talc-injected rats did not develop the enlargement of the spleen, which has been shown to play a central role in the pathogenesis of the immunosuppression induced by talc granulomatosis. Vitamin D3 seems to be important for the generation of the osteoblasts insufficiency in inflammation, as well as for the activation of the immune system in the spleen.

vitamin D3; osteoblast; bone

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