engleski

Met-enkephalin effects on the histamine induced bronchoconstriction in guinea-pigs

We investigated the effects of neuropeptide met-enkephalin on the histamine induced bronhoconstriction in guinea-pigs. Konzett and Rössler's method of whole body pletismography modified by Gjuriš, was applied to investigate the effects. This method represents standard in vivo model of asthma. Dose-related modulatory effect of met enkephalin on the bronchoconstrictor action of histamine was noticed and met enkephalin doses of 1 mg/kg and 10 mg/kg, respectively, caused significant reduction of the histamine induced bronchoconstriction. Further studies are needed to define practical and therapeutical use of the presented observations in chronic obstructive pulmonary diseases.

asthma; bronhoconstriction; guinea-pig; met-enkephalin; modulatory effect

nije evidentirano