Synthesis of the novel bicyclic oxepinopyrimidine and fluorinated pyrrolidinopyrimidines (CROSBI ID 106672)
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Batinac, Sanja ; Mrvoš Sermek, Draginja ; Cetina, Mario ; Pavelić, Krešimir ; Mintas, Mladen ; Raić-Malić, Silvana
engleski
Synthesis of the novel bicyclic oxepinopyrimidine and fluorinated pyrrolidinopyrimidines
The new 5, 6-disubstituted pyrimidine nucleoside analogues (5-8) were synthesized by addition of the C-6 lithiated pyrimidine derivative to oxirane as key reaction step. The bicyclic tetrahydrooxepinopyrimidine (9) and fluorinated pyrrolidinopyrimidines (12 and 15) were obtained by intramolecular linkage of acyclic chain to the CH2-5 and N-1 of the pyrimidine ring. The structure of compound (9) containing pyrimidine and tetrahydrooxepine skeleton was determined unequivocally by its X-Ray crystal structure analysis.
5 ; 6-dialkylated pyrimidine derivatives ; bicyclic pyrimidines ; X-ray crystal structure
Rad je objavljen i u ChemInform (0931-7597) 36 (2015)(15) ; https://onlinelibrary.wiley.com/doi/full/10.1002/chin.200515198 ; https://doi.org/10.1002/chin.200515198
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