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Role of the Hedgehog/Patched signaling pathway in oncogenesis. A new polymorphism in the PTCH gene in ovarian fibroma (CROSBI ID 107071)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Levanat, Sonja ; Musani, Vesna ; Komar, Arijana ; Orešković, Slavko Role of the Hedgehog/Patched signaling pathway in oncogenesis. A new polymorphism in the PTCH gene in ovarian fibroma // Annals of the New York Academy of Sciences, 1030 (2004), 1; 134-143. doi: 10.1196/annals.1329.017

Podaci o odgovornosti

Levanat, Sonja ; Musani, Vesna ; Komar, Arijana ; Orešković, Slavko

engleski

Role of the Hedgehog/Patched signaling pathway in oncogenesis. A new polymorphism in the PTCH gene in ovarian fibroma

We compared the expression of target genes of Hedgehog/patched signaling in ovarian fibromas and ovarian dermoids. We noted that high levels of SHH appear almost regularly, especially in dermoids, usually accompanied by increased expression of SMO. GLI overexpression does not coincide with that of PTCH. Loss of heterozygosity findings in the PTCH locus and increased expression of several genes in the pathway strongly suggest that the pathway is involved in both ovarian fibromas and dermoids.

Hedgehog/patched signaling ; SHH ; SMO ; GLI1 ; PTCH ; PTCH polymorphisms ; ovarian fibromas ; ovarian dermoids

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Podaci o izdanju

1030 (1)

2004.

134-143

objavljeno

0077-8923

1749-6632

10.1196/annals.1329.017

Povezanost rada

Temeljne medicinske znanosti

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