Role of the Hedgehog/Patched signaling pathway in oncogenesis. A new polymorphism in the PTCH gene in ovarian fibroma (CROSBI ID 107071)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Levanat, Sonja ; Musani, Vesna ; Komar, Arijana ; Orešković, Slavko
engleski
Role of the Hedgehog/Patched signaling pathway in oncogenesis. A new polymorphism in the PTCH gene in ovarian fibroma
We compared the expression of target genes of Hedgehog/patched signaling in ovarian fibromas and ovarian dermoids. We noted that high levels of SHH appear almost regularly, especially in dermoids, usually accompanied by increased expression of SMO. GLI overexpression does not coincide with that of PTCH. Loss of heterozygosity findings in the PTCH locus and increased expression of several genes in the pathway strongly suggest that the pathway is involved in both ovarian fibromas and dermoids.
Hedgehog/patched signaling ; SHH ; SMO ; GLI1 ; PTCH ; PTCH polymorphisms ; ovarian fibromas ; ovarian dermoids
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Podaci o izdanju
1030 (1)
2004.
134-143
objavljeno
0077-8923
1749-6632
10.1196/annals.1329.017
Povezanost rada
Temeljne medicinske znanosti