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izvor podataka: crosbi

The age related decline of perforin expression in human cytotoxic T lymphocytes and natural killer cells (CROSBI ID 81136)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Rukavina, Daniel ; Laškarin, Gordana ; Rubeša, Gordana ; Štrbo, Nataša ; Bedenicki, Ivica ; Manestar, Darko ; Glavaš, Mario ; Christmas, Stephen E. ; Podack, Eckhard R. The age related decline of perforin expression in human cytotoxic T lymphocytes and natural killer cells // Blood, 92 (1998), 7; 2410-2420-x

Podaci o odgovornosti

Rukavina, Daniel ; Laškarin, Gordana ; Rubeša, Gordana ; Štrbo, Nataša ; Bedenicki, Ivica ; Manestar, Darko ; Glavaš, Mario ; Christmas, Stephen E. ; Podack, Eckhard R.

engleski

The age related decline of perforin expression in human cytotoxic T lymphocytes and natural killer cells

In this study a flow cytometric technique for detecting cytoplasmic perforin (P) has been employed to quantify age-related changes in perforin expression in human peripheral blood lymphocytes. Proportions of P+ lymphocytes increased after birth but declined rapidly after the age of 70 years. This was true for both T cells and CD16+ and CD56+ NK cells. Children showed in addition to high levels of perforin positive CD8+ cells a much higher proportion of CD4+P+ cells than the other age groups. In elderly individuals there was also a highly significant reduction in mean levels of perforin per cell as compared with all other groups (p<0.05 - 0.001). Adult women had consistently higher mean levels of perforin per cell than adult men for all P+ cell phenotypes. Functional tests clearly showed the deficiency in early spontaneous cytotoxic potential of PBL from elderly persons due to relative P deficiency, which can be corrected by stimulation of cytolytic cells with target cells and IL-2. The deficiency in cytolytic activity upon the contact with target cells may have implications for antiviral and antitumor immunity in elderly persons.

Perforin; cord blood lymphocytes; peripheral blood lymphocytes; ageing; NK cytotoxicity; T lymphocytes; NK cells

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Podaci o izdanju

92 (7)

1998.

2410-2420-x

objavljeno

0006-4971

Povezanost rada

Kliničke medicinske znanosti

Indeksiranost