engleski

Processing of carbamazepine-PEG 4000 solid dispersions with supercritical carbon dioxide: preparation, characterisation, and in vitro dissolution

The purpose of this study was to apply the atractive technique of the supercritical fluid to the preparation of solvent-free solid dispersions. In particular, the gas antisolvent crystalisation technique (GAS), using supercritical carbon dioxide as processing medium, has been considered to prepare enhanced release dosage form for the poorly soluble carbamazepine, employing PEG 4000 as a hydrophilic carrier.

gas antisolvent crystallisation ; supercritical fluids ; solid dispersions ; carbamazepine ; PEG 4000 ; physico-chemical characterisation

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